June 5, 2023
Title: Advancing Research Through PMedIC: Discovering Collaborative Capabilities with Live Q&A
Dr. Beth Habecker, Professor of Chemical Physiology and Biochemistry, School of Medicine, OHSU
Dr. Bobbie-Jo Webb-Robertson, PMedIC Co-Director, Laboratory Fellow | Health & Human Services (HHS) Sector Manager, Biological Sciences Division, PNNL
Dr. Josh Adkins, PMedIC Co-Director, Laboratory Fellow | Health & Human Services (HHS) Sector Manager, Biological Sciences Division, PNNL
Dr. Jamie Lo, PMedIC Co-Director | Associate Professor, Division of Maternal-fetal Medicine, Department of Obstetrics and Gynecology, OHSU
December 7, 2022
Title: Mapping the Proteogenomic Landscape of Acute Myeloid Leukemia to Enable Prediction of Drug Response
Dr. Cristina Tognon, Scientific Director Druker Lab, OHSU Scientific Liaison (Heme), AZ Partner of Choice Program
Dr. Sara Gosline, Senior Research Scientists, Team Lead, Software & Algorithms, PNNL
September 7, 2022
Title: The Pacific Northwest Center for Cryo-EM
Dr. Steve Reichow, Associate Professor of Biochemistry & Molecular Biophysics, PSU/ Co-Principal Investigator, PNCC
Dr. James Evans, Staff Scientist, Biochemistry, PNNL/ Co-Principal Investigator, PNCC
June 1, 2022
Title: Mass spectrometry-based single cell proteomics for characterization of inner-ear sensory hair cells
Dr. Peter Barr-Gillespie, Professor of Otolaryngology/ Chief Research Officer and Executive Vice President, OHSU
Dr. Ying Zhu, Senior Research Scientist, PNNL
March 2, 2022
Title: Central control of peripheral immune responses
Dr. Daniel Marks, Professor of Pediatrics and Senior Associate Dean for Research, School of Medicine, OHSU
Dr. Sneha Couvillion, Metabolomics, Biomedical Scientist, PNNL
Abstract:
A wide variety of pathogens present an acute survival challenge in humans, and our ability to rapidly and precisely respond to these pathogens is critical to our survival as a species. Although there are some common immune responses to different classes of pathogens (e.g. viruses, bacteria, etc.), effective control and elimination of pathogens requires rapid deployment of immune resources directed specifically at the invading pathogen class. The central nervous system (CNS) is a critical site of sensing and bioamplification of immune signals from invading pathogens. This function is critical in producing behavioral, metabolic, and immunologic adaptations in a pathogen-specific manner to enhance survival.
This project uses an integrative approach of combining multi-omics (metabolomics, lipidomics and transcriptomics) and immunological data — leveraging unique capabilities and expertise at PNNL and OHSU- to obtain a systems-level mechanistic understanding of how the brain differentially modulates peripheral metabolism by sensing bacterial or viral infection.
December 8, 2021
Title: A global lipid map defines a network essential for Zika virus replication
Dr. Jennifer Kyle, Metabolomics, Biomedical Scientist, PNNL
Dr. Fikadu Tafesse, Assistant Professor, Molecular Microbiology and Immunology, School of Medicine, OHSU
September 8, 2021
Title: Clinical Proteogenomic Tumor Analysis Consortium
Dr. Karin Rodland, Laboratory Fellow, Biological Sciences Division, PNNL
Dr. Jeffrey Tyner, Professor, Cell, Developmental, and Cancer Biology, OHSU
June 9, 2021
Title: Applying metabolomics in the characterization of rare disease: Experiences from the NIH Undiagnosed Diseases Network
Dr. David Koeller, Professor of Molecular and Medical Genetics, School of Medicine, OHSU
Dr. Thomas Metz, Metabolomics Team Lead, Biological Sciences Division, PNNL